Top latest Five ceesdekker Urban news
Top latest Five ceesdekker Urban news
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Rotary movement of DNA rotors on nanopores. Prime row: raw online video of your Cy5 channel of every rotor. Middle row: corresponding single-particle localization results of both ends from the DNA rotors. The placement of the current body is marked as orange and blue dots, as well as the trajectory of The ten frames before The existing frame is demonstrated as sound strains.
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‘It was simply just a make any difference of finding up a ebook on cell biology and beginning to read through. I had originate from a entire world of ultra-high vacuums, cryostats and quantum phenomena, and now I had been Functioning at space temperature with molecular biology kits.
I am able to rarely consider how I, for a geneticist, would manage to study elementary physics, let alone compete at the best. How did you go over it?
Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever style and design in 2005. (nl)
SMC complexes can pass Actual physical roadblocks larger than their ring measurement, indicating a nontopological mechanism for DNA loop extrusion
We use nanofabricated microfluidic buildings to sample spatial boundaries for microorganisms and biomimetic vesicles with reconstituted protein networks and this assess the fundamental role of spatial confinement at the molecular and mobile stage. Our initiatives incorporate the next:
Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
The rotors harness Power from the nanoscale drinking water and ion movement that is produced by a static chemical or electrochemical prospective gradient inside the nanopore, that are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and work autonomously in physiological situations, ceesdekker suggesting methods to developing Vitality-transducing motors at nanoscale interfaces.
It absolutely was throughout this period that Dekker completed investigation on magnetic spin devices and on sounds in superconductors and semiconductors.
Testing pseudotopological and nontopological styles for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
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2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental review of ions conduction in nanofluidic channels; very first electrochemistry with individual solitary-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; very first biophysics characterization of the mechanical Houses of double-stranded RNA; and very first one-molecule examine of DNA translocation by a restriction-modification enzyme.